Tuesday, April 30, 2013

Syrian TV: Explosion in Damascus causes casualties

DAMASCUS, Syria (AP) ? Syrian state TV and residents of Damascus say a powerful explosion has hit the country's capital.

The nature of Tuesday's explosion in the heart of Damascus was not immediately clear. Resident say they heard a powerful blast and saw thick, black smoke billowing from behind a group of buildings.

Gunfire was heard in the area immediately after the Tuesday morning blast.

Syrian TV says the explosion occurred in the central district of Marjeh, although the target was not immediately clear.

The blast comes a day after Syria's prime minister narrowly escaped an assassination attempt in the heavily protected area of Damascus.

Source: http://news.yahoo.com/syrian-tv-explosion-damascus-causes-casualties-085518378.html

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OpenMobile ACL for webOS resurrected on Kickstarter, hopes to bring Android apps to HP Touchpad

OpenMobile ACL for webOS resurrected on Kickstarter, hopes to bring Android apps to HP Touchpad

The promise of OpenMobile's Application Compatibility Layer is enticing: seamlessly run Android apps on another operating system as if it was meant to be there. Unfortunately for fans of Palm's last hurrah, the project's webOS port died with the HP Touchpad. That won't stop dedicated fans, however -- Phoenix International Communications plans to resurrect webOS ACL. Taking the project to Kickstarter, the team is showing an early build on an HP Touchpad, seamlessly running Android apps in cards alongside native webOS applications. Phoenix hopes that a functional ACL will reduce Touchpad owner's reliance on dual-booting Android, giving them the freedom to enjoy webOS without sacrificing functionality. The team is promising a relatively short development time, thanks to OpenMobile's early work, and hopes to deliver a consumer ready build in July. But first the Kickstarter campaign will need to meet its $35,000 goal. Interested in pitching in? Check out the Kickstarter link at the source.

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Source: Kickstarter

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/qcUvqY4TqGI/

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Residents concerned about health effects of hydrofracking

Apr. 28, 2013 ? s living in areas near natural gas operations, also known as hydraulic fracturing, or fracking, are concerned their illnesses may be a result of nearby drilling operations. Twenty-two percent of the participants in a small pilot study surmise that hydrofracking may be the cause of such health concerns as sinus problems, sleeping difficulties, and gastrointestinal problems.

The findings will be presented at the American Occupational Health Conference on April 28 in Orlando, Florida.

Scientists collected responses from 72 adults visiting a primary care physician's office in the hydrofracking-heavy area of Bradford County, Pa., who volunteered to complete an investigator-faciliated survey.

"Almost a quarter of participants consider natural gas operations to be a contributor to their health issues, indicating that there is clearly a concern among residents that should be addressed," says Poun? Saberi, MD, MPH, the study's principal investigator with the department of Occupational and Environmental Medicine at the Perelman School of Medicine, University of Pennsylvania. She is also an investigator with the Center of Excellence in Environmental Toxicology (CEET) at Penn.

Within these 22 percent of responders, 13 percent viewed drilling to be the cause of their current health complaints and 9 percent were concerned that future health problems can be caused by natural gas operations. The previous health complaints by participants were thought to be anecdotal in nature as they were individual cases reported publicly only by popular media.

"What is significant about this study is that the prevalence of impressions about medical symptoms attributed to natural gas operations had not been previously solicited in Pennsylvania. This survey indicates that there is a larger group of people with health concerns than originally assumed," explains Saberi.

The survey included questions about 29 health symptoms, including those previously anecdotally reported by other residents and workers in other areas where drilling occurs. Some patient medical records were also reviewed to compare reported symptoms with those that had been previously documented. "Sinus problems, sleeping difficulties, and gastrointestinal problems were the most common symptoms reported on the Bradford survey," notes Saberi. "Of the few studied charts, there were no one-to-one correlations between the participants' reported symptoms on the survey and the presenting symptom to the medical provider in the records. This raises the possibility of communication gaps between residents with concerns and the medical community and needs further exploration. An opportunity exists to educate shale region communities and workers to report, as well as health care providers to document, the attributed symptoms as precisely as possible."

The CEET team also mapped the addresses of patients who agreed to provide them in relation to drilling to determine if proximity to drilling operations may relate to health problems.

"We hope this pilot study will guide the development of future epidemiological studies to determine whether health effects in communities in which natural gas operations are occurring is associated with air, water, and food-shed exposures and will provide a basis for health care provider education," says CEET director Trevor Penning, PhD. "The goal of science should be to protect the public and the environment before harm occurs; not simply to treat it after the damage has been done."

The Bradford County health concerns pilot study is one of three hydrofracking studies currently underway at CEET, one of 20 Environmental Health Sciences Core Centers (EHSCC) in the US, funded by the National Institutes of Environmental Health Sciences (NIEHS).

CEET is also partnering with Columbia University's EHSCC to measure water quality and billable health outcomes in areas with and without hydrofracking on the Pennsylvania-New York border. Using a new mapping tool developed by Harvard University, CEET and Harvard researchers are creating maps of drilling sites, air quality, water quality, and health effects to locate possible associations. Initial studies will focus on Pennsylvania. Results of both studies are expected in early 2014. These collaborative studies are funded by pilot project funds from the respective EHSCCs, which in turn obtain their financial support from NIEHS.

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The above story is reprinted from materials provided by University of Pennsylvania School of Medicine, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/IVvBTUbZKJQ/130428230423.htm

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Monday, April 29, 2013

Cat and mouse: One gene is necessary for mice to avoid predators

Apr. 29, 2013 ? When a mouse smells a cat, it instinctively avoids the feline or risks becoming dinner. How? A Northwestern University study involving olfactory receptors, which underlie the sense of smell, provides evidence that a single gene is necessary for the behavior.

A research team led by neurobiologist Thomas Bozza has shown that removing one olfactory receptor from mice can have a profound effect on their behavior. The gene, called TAAR4, encodes a receptor that responds to a chemical that is enriched in the urine of carnivores. While normal mice innately avoid the scent marks of predators, mice lacking the TAAR4 receptor do not.

The study, published April 28 in the journal Nature, reveals something new about our sense of smell: individual genes matter.

Unlike our sense of vision, much less is known about how sensory receptors contribute to the perception of smells. Color vision is generated by the cooperative action of three light-sensitive receptors found in sensory neurons in the eye. People with mutations in even one of these receptors experience color blindness.

"It is easy to understand how each of the three color receptors is important and maintained during evolution," said Bozza, an author of the paper, "but the olfactory system is much more complex."

In contrast to the three color receptors, humans have 380 olfactory receptor genes, while mice have more than 1,000. Common smells like the fragrance of coffee and perfumes typically activate many receptors.

"The general consensus in the field is that removing a single olfactory receptor gene would not have a significant effect on odor perception," said Bozza, an assistant professor of neurobiology in the Weinberg College of Arts and Sciences.

Bozza and his colleagues tested this assumption by genetically removing a specific subset of olfactory receptors called trace amine-associated receptors, or TAARs, in mice. Mice have 15 TAARs. One is expressed in the brain and responds to amine neurotransmitters and common drugs of abuse such as amphetamine. The other 14 are found in the nose and have been coopted to detect odors.

Bozza's group has shown that the TAARs are extremely sensitive to amines -- a class of chemicals that is ubiquitous in biological systems and is enriched in decaying materials and rotting flesh. Mice and humans typically avoid amines since they have a strongly unpleasant, fishy quality.

Bozza's team, including the paper's lead authors, postdoctoral fellow Adam Dewan and graduate student Rodrigo Pacifico, generated mice that lack all 14 olfactory TAAR genes. These mice showed no aversion to amines. In a second experiment, the researchers removed only the TAAR4 gene. TAAR4 responds selectively to phenylethylamine (PEA), an amine that is concentrated in carnivore urine. They found that mice lacking TAAR4 fail to avoid PEA, or the smell of predator cat urine, but still avoid other amines.

"It is amazing to see such a selective effect," Dewan said. "If you remove just one olfactory receptor in mice, you can affect behavior."

The TAAR genes are found in all mammals studied so far, including humans. "The fact that TAARs are highly conserved means they are likely important for survival," Bozza said.

One idea is that the TAARs may make animals very sensitive to the smell of amines. Humans may have TAAR genes to avoid rotting foods, which become enriched in amines during the decomposition process. In fact, the TAARs may relay information to a specific part of the brain that elicits innately aversive behavior in animals.

Bozza's lab has recently shown that neurons in the nose that express the TAARs connect to with a specific region of the olfactory bulb -- the part of the brain that first receives olfactory information. This suggests that the TAARs may elicit hardwired responses to amines in mice, and perhaps humans.

"We hope this work will reveal specific brain circuits that underlie instinctive behaviors in mammals," Bozza said. "Doing so will help us understand how neural circuits contribute to behavior."

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Journal Reference:

  1. Adam Dewan, Rodrigo Pacifico, Ross Zhan, Dmitry Rinberg, Thomas Bozza. Non-redundant coding of aversive odours in the main olfactory pathway. Nature, 2013; DOI: 10.1038/nature12114

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/LHj98X5KInQ/130429154115.htm

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OpenMobile ACL for webOS resurrected on Kickstarter, hopes to bring Android apps to HP Touchpad

OpenMobile ACL for webOS resurrected on Kickstarter, hopes to bring Android apps to HP Touchpad

The promise of OpenMobile's Application Compatibility Layer is inciting: seamlessly run Android apps on another operating system as if it was meant to be there. Unfortunately for fans of Palm's last hurrah, the project's webOS port died with the HP Touchpad. That won't stop dedicated fans, however -- Phoenix International Communications plans to resurrect webOS ACL. Taking the project to Kickstarter, the team has showed an early build of the project on an HP Touchpad, seamlessly running Android apps in cards alongside native webOS applications. Phoenix hopes that a functional ACL will reduce Touchpad owner's reliance on dual-booting Android, giving them the freedom to enjoy webOS without sacrificing functionality. The team is promising a relatively short development time, thanks to OpenMobile's early work, and hopes to deliver a consumer ready build in July. But first the Kickstarter campaign will need to meet its $35,000 goal. Interested in pitching in? Check out the Kickstarter link at the source.

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Source: Kickstarter

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/qcUvqY4TqGI/

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Sunday, April 28, 2013

FAA: Air traffic system soon at full operation

A United Airlines jet departs in view of the air traffic control tower at Seattle-Tacoma International Airport Tuesday, April 23, 2013, in Seattle. A day after flight delays plagued much of the U.S., air travel is smoother Tuesday. But the government is warning passengers that the situation can change by the hour as it runs the nation's air traffic control system with a smaller staff. Airlines and members of Congress urged the Federal Aviation Administration to find other ways to make mandatory budget cuts besides furloughing controllers. While delays haven't been terrible yet, the airlines are worried about the long-term impact late flights will have on their budgets and on fliers. (AP Photo/Elaine Thompson)

A United Airlines jet departs in view of the air traffic control tower at Seattle-Tacoma International Airport Tuesday, April 23, 2013, in Seattle. A day after flight delays plagued much of the U.S., air travel is smoother Tuesday. But the government is warning passengers that the situation can change by the hour as it runs the nation's air traffic control system with a smaller staff. Airlines and members of Congress urged the Federal Aviation Administration to find other ways to make mandatory budget cuts besides furloughing controllers. While delays haven't been terrible yet, the airlines are worried about the long-term impact late flights will have on their budgets and on fliers. (AP Photo/Elaine Thompson)

The control tower stands in the background as a passenger lays on the pavement outside the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta. Congress easily approved legislation Friday ending furloughs of air traffic controllers that have delayed hundreds of flights daily, infuriating travelers and causing political headaches for lawmakers.(AP Photo/David Goldman)

A passenger sits at right in the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta. Congress easily approved legislation Friday ending furloughs of air traffic controllers that have delayed hundreds of flights daily, infuriating travelers and causing political headaches for lawmakers.(AP Photo/David Goldman)

The control tower stands in the background as a passenger paces while on the phone outside the international terminal at Hartsfield-Jackson airport, Friday, April 26, 2013, in Atlanta. Congress easily approved legislation Friday ending furloughs of air traffic controllers that have delayed hundreds of flights daily, infuriating travelers and causing political headaches for lawmakers.(AP Photo/David Goldman)

(AP) ? The Federal Aviation Administration said that the U.S. air traffic system will resume normal operations by Sunday evening after lawmakers rushed a bill through Congress allowing the agency to withdraw furloughs of air traffic controllers and other workers.

The FAA said Saturday that it has suspended all employee furloughs and that traffic facilities will begin returning to regular staffing levels over the next 24 hours. The furloughs were fallout from the $85 billion in automatic-across-the-board spending cuts this spring.

The furloughs started to hit air traffic controllers this past week, causing flight delays that left thousands of travelers frustrated and furious. Planes were forced to take off and land less frequently, so as not to overload the remaining controllers on duty.

The FAA had no choice but to cut $637 million as its share of $85 billion in automatic, government-wide spending cuts that must be achieved by the end of the federal budget year on Sept. 30.

Flight delays piled up across the country Sunday and Monday of this week as the FAA kept planes on the ground because there weren't enough controllers to monitor busy air corridors. Cascading delays held up flights at some of nation's busiest airports, including New York, Baltimore and Washington. Delta Air Lines canceled about 90 flights Monday because of worries about delays. Just about every passenger was rebooked on another Delta flight within a couple of hours. Air travel was smoother Tuesday.

Things could have been worse. A lot of people who had planned to fly this week changed their plans when they heard that air travel might be difficult, according to longtime aviation consultant Daniel Kasper of Compass Lexicon.

"Essentially what happened from an airline's perspective is that people who were going to travel didn't travel," he said. But canceled flights likely led to lost revenue for airlines. Even if they didn't have to incur some of costs of fueling up planes and getting them off the ground, crews that were already scheduled to work still had to paid.

"One week isn't going to kill them, but had it gone on much longer, it would have been a significant hit on their revenues and profits," Kasper said.

The challenges this week probably cost airlines less than disruptions from a typical winter storm, said John F. Thomas, an aviation consultant with L.E.K. Consulting.

"I think the fact that it got resolved this week has minimized the cost as it was more the inconvenience factor," Thomas said.

The budget cuts at the FAA were required under a law enacted two years ago as the government was approaching its debt limit. Democrats were in favor of raising the debt limit without strings attached so as not to provoke an economic crisis, but Republicans insisted on substantial cuts in exchange. The compromise was to require that every government "program, project and activity" ? with some exceptions, like Medicare ? be cut equally.

The FAA had reduced the work schedules of nearly all of its 47,000 employees by one day every two weeks, including 15,000 air traffic controllers, as well as thousands of air traffic supervisors, managers and technicians who keep airport towers and radar facility equipment working. That amounted to a 10 percent cut in hours and pay.

Republicans accused the Obama administration of forcing the furloughs to raise public pressure on Congress to roll back the budget cuts. Critics of the FAA insist the agency could have reduce its budget in other ways that would not have inconvenience travelers including diverting money from other accounts, such as those devoted to research, commercial space transportation and modernization of the air traffic control computers.

President Barack Obama chided lawmakers Saturday over their fix for widespread flight delays, deeming it an irresponsible way to govern, dubbing it a "Band-Aid" and a quick fix, rather than a lasting solution to the spending cuts known as the sequester.

"Republicans claimed victory when the sequester first took effect, and now they've decided it was a bad idea all along," Obama said, singling out the GOP even though the bill passed with overwhelming Democratic support in both chambers.

He scolded lawmakers for helping the Federal Aviation Administration while doing nothing to replace other cuts that he said harm federal employees, unemployed workers and preschoolers in Head Start.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-27-US-FAA-Furloughs/id-ff266ec5f2524584b286063a61123c2e

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Don't blame Canada: Former ambassador to Iran on Argo, America, and nukes

Canada's envoy to Tehran at the time of the Islamic revolution and the US hostage crisis, says Argo disappointed him and that he's worried about where Iran's nuclear program might lead.

By Ariel Zirulnick,?Staff writer / April 26, 2013

Former Canadian Ambassador to Iran Ken Taylor and his wife Pat, pose for photographers at the premiere of the film Argo in Washington, Oct. 2012. Taylor, who protected Americans at great personal risk during the Iran hostage crisis of 1979, has achieved some name recognition in the US since the 2012 movie 'Argo' swept theaters and the Academy Awards.

Cliff Owen/AP/File

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Former Canadian Ambassador Ken Taylor is neither the James Bond lookalike he hoped might portray him in the Hollywood blockbuster "Argo" nor is he quite the Austin Powers double he says might have been a more accurate choice.

Skip to next paragraph Ariel Zirulnick

Middle East Editor

Ariel Zirulnick is the Monitor's Middle East editor, overseeing regional coverage both for CSMonitor.com and the weekly magazine. She is also a contributor to the international desk's terrorism and security blog.?

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But he's achieved some name recognition in the US since the 2012 movie swept theaters and the Academy Awards, and he has plenty to say about Iran in 1979 and the country it has become since.?

Mr. Taylor was Canada's ambassador to Tehran in 1979 when the US embassy there was stormed and dozens of Americans were taken hostage. Six Americans escaped and spent months holed up with him, waiting for their extraction.

Those months are the premise of the Ben Affleck-directed movie, which Taylor mildly says took ?a bit of poetic license.?

Speaking before a gathering of the New England Canada Business Council in Boston yesterday, Taylor, who now lives in New York, joked that after friends saw "Argo" at the 2012 Toronto Film Festival, they called him and said, ?I thought Canada was involved.?

According to Taylor, he replied, ?That?s odd, So did I.?

As the tense months of being trapped inside the embassy wore on, Taylor tried to reassure the Americans that they would be home by Thanksgiving, then Christmas, then the Super Bowl. He warned the US that ?they?re going to wonder if Washington forgot about them.?

Taylor revealed little about the actual operation that got the six men and women safely back to the United States. But, he joked, at least the movie showed that he ?opened the front door of the embassy with great dexterity.?

Iran then

When Taylor arrived in Tehran in 1977, ?the country was booming.?

There were rumors that Mohammed Reza Shah Pahlavi ? more commonly referred to as simply ?the Shah? ? was preparing to buy Pan American Airways. It did not seem like the ?stalwart of the West? was going anywhere.

For all the blame heaped on the Central Intelligence Agency (CIA) for not predicting the Islamic Revolution, almost nobody saw it coming, he said. Afterward, the Ayatollah?s secular advisers told Taylor that even they didn?t expect the Shah?s government to fall like it did. ?

Revolutionary fervor did not sweep up the whole country the way it seemed to be portrayed in "Argo." And Taylor said a great disappointment for him was the way the movie portrayed Iranians, some of whom became ?marvelous friends? with him during his posting in Tehran.

?The movie was too heavy handed,? he said. ?It gave no idea that there is another side to the Iranian character. Everybody isn?t on the street. Everybody isn?t part of the revolution.?

Too many sanctions, too little talking

He is on board with the growing chorus of voices in Washington urging the Obama administration to ease up on its sanctions-heavy approach to negotiations with Iran although he acknowledges that Iran needs to give ground too.

Sometimes sanctions work, he says, citing South Africa during the apartheid era, but ?sometimes they strengthen resolve.?

When asked his opinion of whether Tehran has nuclear weapon ambitions, he cautions that ?Iran is an opaque society,? and there?s too little information to guess.

?I think they?ve got some military use in the back of their mind,? he says. ?But they don?t want to destroy themselves ? Maybe they are working at capabilities, but not necessarily producing [a nuclear weapon].?

That the military option for halting Iran?s nuclear development is ?on the table? worries Taylor, who points to the wars in Iraq and Afghanistan as cautionary for anyone considering going to war with Iran.

"A bombing mission would be a fatal error. It would solve nothing,? he says. ?It would postpone [Iran?s nuclear program] for two to three years,? but nothing more, because Iran?s nuclear facilities are too dispersed.

He says, ?I wake up every morning hoping [the military option] is still on the table? ? instead of being used.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/hjWdZ6cfd7U/Don-t-blame-Canada-Former-ambassador-to-Iran-on-Argo-America-and-nukes

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Stocks stall on tepid US economic growth

NEW YORK (AP) ? The stock market stalled Friday after the U.S. economy didn't grow as much as hoped and earnings from a handful of big companies failed to rev up investors.

The economy grew at a 2.5 percent annual rate in the first three months of the year, the government said. That was below the 3.1 percent forecast by economists.

The shortfall reinforced the perception that the economy is grinding, rather than charging, ahead. Investors have also been troubled by reports in the last month of weaker hiring, slower manufacturing and a drop in factory orders. Many economists see growth slowing to an annual rate of around 2 percent a year for the rest of the year.

U.S. government bonds, where investors seek safety, rose after the report.

"There are some concerns as we head into the summer," said JJ Kinahan, chief derivatives strategist for TD Ameritrade. "In the last three weeks, we've seen numbers that weren't exactly what you'd love to see."

Corporate earnings this week have also contained worrisome signs. Many companies missed revenue forecasts from financial analysts, even as they reported higher quarterly profits. For example, Goodyear Tire slipped 3.3 percent to $12.51 Friday after revenue fell short of analysts' estimates, hurt by lower global tire sales.

Of the companies that have reported earnings so far, 70 percent have exceeded Wall Street's expectations, compared with a 10-year average of 62 percent, according to S&P Capital IQ. But 43 percent have missed revenue estimates. Just over half of the companies in the S&P 500 have reported quarterly results.

The S&P 500 index dropped 2.92 points, or 0.2 percent, to close at 1,582.24.

The Dow rose 11.75 points, or 0.1 percent, to 14,712.55. The index got a big lift from Chevron. Profit for the U.S. oil company beat expectations of financial analysts in the first quarter, pushing shares up 1.3 percent to $120.04.

Three stocks fell for every two that rose on the New York Stock Exchange.

Both indexes were up for the week and remain slightly below their all-time highs reached April 11. The Dow index rose 1.1 percent this week while the S&P gained 1.7 percent.

The market has been bolstered by the Federal Reserve's easy money policy. The disappointing growth figure for the economy will ensure that the Fed sticks with its stimulus policy, providing support for stocks, said Peter Cardillo, chief market economist at Rockwell Global Capital.

"The economic data that we've been getting points to no early exit for the Fed's stimulus," Cardillo said.

The Nasdaq composite fell 10.72 points to 3,279.26, a decline of 0.3 percent. The index is 2.3 percent higher this week.

The tech-heavy index has lagged the Dow and the S&P 500 this year, but it led the way higher this week, boosted by Microsoft. The software giant, which makes up 5.3 percent of the Nasdaq, recorded its biggest weekly gain since January of last year ? up 6.8 percent. It reported earnings April 19 that beat Wall Street expectations. The company also began an aggressive push into the computer tablet market.

Apple, the largest stock in the Nasdaq, also had a good week. The stock rose 6.8 percent to $417.20, its best weekly gain since November, despite posting a decline in quarterly profit Tuesday. Apple accounts for 7.6 percent of the Nasdaq composite.

Among other big names investors focused on:

Amazon.com fell 7 percent to $254.81 after the company warned of a possible loss in the current quarter. The online retailer also reported lower income for the first quarter as it continued to spend heavily on rights to digital content.

Expedia fell 10 percent to $58.56 after the online travel company reported a quarterly loss.

Homebuilder D.R. Horton surged 8.7 percent to $26.66 after its income nearly tripled thanks to a continuing recovery the housing market. The results handily beat the forecasts of financial analysts who follow the company.

J.C. Penney jumped 12 percent to $17 after the billionaire financier George Soros disclosed that he had taken a 7.9 percent stake in the struggling company.

In government bond trading, the yield on the 10-year Treasury note slipped to its lowest rate of the year, 1.67 percent, from 1.71 percent the day before. The yield has fallen from 2.06 percent six weeks ago as traders move money into lower-risk investments.

The dollar weakened against the euro.

The European currency bought $1.3029 at the end of day, compared with $1.3002 the day before. The ISE dollar index, which measures the U.S. currency against a group of other world currencies including the Japanese yen and the euro, dropped 0.3 percent, to 82.48.

Source: http://news.yahoo.com/stocks-stall-tepid-us-economic-growth-195845422.html

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KC Rep find the gritty humor in David Mamet's 'American Buffalo ...

The early plays of David Mamet are never classified as comedies, but the fine Kansas City Repertory Theatre production of ?American Buffalo? poses an obvious question: Why not?

It could be that Mamet himself projects such a humorless public persona in interviews and his personal essays that ?funny? is a word we resist attaching to a man who discusses his plays as intellectual exercises. Although we still encounter flashes of the poetically profane old Mamet (he was certainly present in ?Phil Spector,? the recent HBO film he wrote and directed), he has through the years seemed drawn to the elevated language of by-gone eras in such as plays as ?Boston Marriage,? his adaptation of the Edwardian drama ?The Voysey Inheritance? or his film version of British playwright Terence Rattigan?s ?The Winslow Boy.?

In ?American Buffalo? we encounter ?classic? Mamet. The dialogue in this 1975 play, which established him as a major talent, is raw but precise and the setting is far from anything resembling middle-class respectability.

Set in a ?resale? shop in Chicago, the piece depicts the bumbling efforts of a trio of sub-cultural bottom-feeders to pull off a rare-coins heist ? a crime for which they are woefully unprepared. The crusty shop owner, Don, has enlisted the help of Bobby, a slow-thinking young junkie who may or may not be clean. But when the bombastic Teach, a neighborhood character with no obvious means of supporting himself, learns of the plan, he convinces Don that Bobby is too inexperienced and untrustworthy to pull off the job. Only he, Teach, can grab the coins without breaking a sweat.

As the plan emerges, we realize that Teach is a big talker who doesn't really possess the requisite criminal skills he claims to have. But he plants enough doubt in Don's mind that the older man comes to distrust Bobby. There's a flash of violence as the little scheme comes unraveled and ultimately we're led to believe that talking big and indulging in grandiose fantasies is really what connects these guys. It's a sort of a mutual delusion society.

In the final minutes of the play, it all comes down to one question Teach repeats to Don: ?Are you mad at me? Are you mad at me?? And there you have it. These guys talk tough but are as emotionally vulnerable as little kids.

?American Buffalo? is generally considered a scathing commentary on market capitalism as these would-be thieves make plans in a shop filled to the rafters with the detritus of American consumerism. That view of the play is totally legitimate, but director Jerry Genochio and his splendid cast see the piece as something beyond that: A comedy of manners. The story of these aspiring master criminals is a near-farcical portrait of little men who want to think big.

As written, Teach becomes the dominant character in the piece. He's a guy who throws his emotional weight around but whose efforts to manipulate others usually comes to nothing. Brian Paulette offers a spectacular performance in this iconic role. Costumed in a leather jacket and florid shirt, with slicked-back hair and a drooping mustache, he visually brings to mind Dustin Hoffman's career criminal in ?Straight Time.? His handling of Mamet's staccato dialogue and profane arias is a thing of beauty. Ultimately Paulette allows us to see beyond the bombast to the inner life of a character who thinks and acts like an addict, even if Bobby is the ?real? junkie.

As Don, Robert Elliott strikes just the right balance as a guy who has cast himself as a paternal figure to young Bobby ? which makes his distrust of the kid all the more disturbing when Teach convinces him that Bobby is a turncoat. Teach and Don have something in common ? an ability to consider superficial evidence and come to the wrong conclusion.

Elliott and Paulette deliver operatic performances. Their characters express themselves in high-relief terms, using words like weapons and reacting to events with extreme emotions. Robbie Tann finds a different vocabulary as Bobby and delivers an utterly convincing human-scale performance as a kid who's the walking personification of vulnerability. Genochio has the skill to put these performances together into a coherent whole. One thing the actors share is immaculate timing. They guide us through the deceptively complex narrative with impressive clarity.

Anyone who saw the 1995 film of ?American Buffalo? knows just how deadly and humorless Mamet can be in the wrong hands. Here he's in very good hands. The result is an impressive portrait of humanity at the bottom of the social scale. It?s funny, sad, poignant and a little scary.

Helping Genochio and his actors to achieve something so raw and yet sublime is a superior design team. Patrick Holt (costumes), Jason Lyons (lighting) and Joe Cerqua (sound and music) all make vital contributions. Scenic designer Donald Eastman deserves special notice because his junk shop is so beautifully cluttered and so spatially dynamic that it virtually becomes a character.

Source: http://www.kansascity.com/2013/04/27/4205600/kc-rep-find-the-gritty-humor-in.html

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Saturday, April 27, 2013

The 5 most shocking WWE Draft picks

As collegiate hopefuls taste gridiron glory ? or crushing disappointment ? in the 2013 NFL Draft, the WWE Universe is instantly reminded of a Raw and SmackDown tradition unseen since 2011: the WWE Draft.

Created in 2002 as part of a Brand Extension that transformed the blue and red brands into two distinct entities, the WWE Draft became a yearly tradition two years later, granting?Raw and?SmackDown General Managers the opportunity to reshape their rosters. The annual event, as Mr. McMahon put it, was a recurrent opportunity to ?shake things up again.?

And boy, did things get shaken up. From stunning defections to catalysts for chaos, the WWE Draft altered the sports-entertainment landscape on multiple occasions. But which draft picks dropped the most jaws? Here are the five biggest WWE Draft shockers.

Source: http://www.wwe.com/classics/classic-lists/shocking-wwe-draft-picks

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Monsters University Trailer: Arrived!

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Friday, April 26, 2013

Sickle cell disease accounts for many priapism cases

By Andrew M. Seaman

NEW YORK (Reuters Health) - Thanks to commercials for erectile dysfunction drugs, men know to seek medical attention for "erections lasting more than four hours," but a new study suggests a blood disorder is the cause of many prolonged erections.

While the condition - formally known as priapism - is rare, researchers report in The Journal of Urology that between 14 percent and 30 percent of cases that show up in U.S. emergency rooms are men with sickle-cell disease.

"I would say what the paper is telling us is that sickle-cell disease is still responsible for the bulk of the visits for priapism," said Dr. Gregory Broderick, professor of urology at the Mayo Clinic in Jacksonville, Florida, who was not involved in the study.

Sickle-cell disease is an inherited disorder that leads to red blood cells containing an abnormal type of hemoglobin. The defective cells frequently take on a sickle- or crescent-shape and can block small blood vessels, which can lead to tissue damage or even stroke.

Especially dangerous for people with the sickle-cell trait is becoming dehydrated, which thickens the blood and can provoke a potentially fatal "sickle-cell crisis."

Other complications of the condition are anemia, jaundice, gallstones, severe leg and arm pain, and spleen, liver and kidney damage.

Previous studies have linked priapism to sickle-cell disease, as well as to illegal drug abuse and use of erectile dysfunction treatments.

To get a better idea of who is most likely to experience priapism, and why, researchers led by the University of Montreal Health Center's Dr. Florian Roghmann analyzed a database of U.S. ER visits between 2006 and 2009.

They found that 32,462 men came to ERs with priapism during that period, which works out to be less than one emergency visit per 100,000 U.S. men. Of those patients, about 13 percent ended up being admitted to the hospital.

The figures were not significantly different from the past, according to the researchers, which suggests the problem is not becoming more common as the population ages.

About half the men were treated at urban teaching hospitals. And about 14 percent of were reported to have sickle-cell disease, but that number was even higher - about 31 percent - among patients younger than 18 years old. About 4 percent of the patients said they had abused drugs.

The study did not assess how many of the men had used erectile dysfunction drugs. Nor could the researchers tell from the data how many of the ER visits were by the same patients.

But the high proportion of patients identified as having sickle-cell disease, according to Broderick, suggests sickle-cell is the main driver of priapism.

"You're really talking about a demographic slice," said Broderick, who has researched priapism but wasn't involved with the new study.

Sickle-cell disease is most common among people of African, especially West African, descent.

The condition is not thought to cause priapism directly by clogging blood vessels with damaged cells. Rather, it's believed that when the defective red blood cells break, their contents in the bloodstream interfere with signaling from the brain that regulates blood flow and tissue responses, according to Broderick.

The study team also found that priapism is more common during the summer months and in warmer climates. Broderick said that may be due to dehydration among people with sickle-cell disease.

But he cautioned that the new study cannot say for certain what caused priapism in these patients. So the researchers can't rule out other explanations.

Regardless of the cause, Broderick told Reuters Health that the condition can lead to serious long-term complications if it's not treated quickly.

"It's a time-dependant emergency. The more time they've had the ischemic or erect penis, the more likely they're going to have erectile dysfunction," he said.

SOURCE: http://bit.ly/ZQU1Kp The Journal of Urology, online April 10, 2013.

Source: http://news.yahoo.com/sickle-cell-disease-accounts-many-priapism-cases-214840442.html

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Novel approach to find RNAs involved in long-term memory storage

Apr. 25, 2013 ? Despite decades of research, relatively little is known about the identity of RNA molecules that are transported as part of the molecular process underpinning learning and memory.

Now, working together, scientists from the Florida campus of The Scripps Research Institute (TSRI), Columbia University and the University of Florida, Gainesville, have developed a novel strategy for isolating and characterizing a substantial number of RNAs transported from the cell-body of neuron (nerve cell) to the synapse, the small gap separating neurons that enables cell to cell communication.

Using this new method, the scientists were able to identify nearly 6,000 transcripts (RNA sequences) from the genome of Aplysia, a sea slug widely used in scientific investigation.

The scientists' target is known as the synaptic transcriptome -- roughly the complete set of RNA molecules transported from the neuronal cell body to the synapse.

In the study, published recently in the journal Proceedings of the National Academy of Sciences, the scientists focused on the RNA transport complexes that interact with the molecular motor kinesin; kinesin proteins move along filaments known as microtubules in the cell and carry various gene products during the early stage of memory storage.

While neurons use active transport mechanisms such as kinesin to deliver RNA cargos to synapses, once they arrive at their synaptic destination that service stops and is taken over by other, more localized mechanisms -- in much the same way that a traveler's bags gets handed off to the hotel doorman once the taxi has dropped them at the entrance.

The scientists identified thousands of these unique sequences of both coding and noncoding RNAs. As it turned out, several of these RNAs play key roles in the maintenance of synaptic function and growth.

The scientists also uncovered several antisense RNAs (paired duplicates that can inhibit gene expression), although what their function at the synapse might be remains unknown.

"Our analyses suggest that the transported RNAs are surprisingly diverse," said Sathya Puthanveettil, a TSRI assistant professor who designed the study. "It also brings up an important question of why so many different RNAs are transported to synapses. One reason may be that they are stored there to be used later to help maintain long-term memories."

The team's new approach offers the advantage of avoiding the dissection of neuronal processes to identify synaptically localized RNAs by focusing on transport complexes instead, Puthanveettil said. This new approach should help in better understanding changes in localized RNAs and their role in local translation as molecular substrates, not only in memory storage, but also in a variety of other physiological conditions, including development.

"New protein synthesis is a prerequisite for maintaining long term memory," he said, "but you don't need this kind of transport forever, so it raises many questions that we want to answer. What molecules need to be synthesized to maintain memory? How long is this collection of RNAs stored? What localized mechanisms come into play for memory maintenance? "

In addition to Puthanveettil, who was the first author of the study, authors of "A Strategy to Capture and Characterize the Synaptic Transcriptome," include Igor Antonov, Sergey Kalchikov, Priyamvada Rajasethupathy, Yun-Beom Choi, Maxime Kinet, Irina Morozova, James J. Russo, and Jingyue Ju of Columbia University; Kevin A. Karl of the Howard Hughes Medical Institute; and Eric R. Kandel of Columbia University, the Howard Hughes Medical Institute and the Kavli Institute for Brain Science; and Andrea B. Kohn, Mathew Citarella, Fahong Yu and Leonid L. Moroz of the University of Florida, Gainesville.

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Story Source:

The above story is reprinted from materials provided by Scripps Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. S. V. Puthanveettil, I. Antonov, S. Kalachikov, P. Rajasethupathy, Y.-B. Choi, A. B. Kohn, M. Citarella, F. Yu, K. A. Karl, M. Kinet, I. Morozova, J. J. Russo, J. Ju, L. L. Moroz, E. R. Kandel. A strategy to capture and characterize the synaptic transcriptome. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1304422110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/85kflBHkj3M/130425160216.htm

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PSY, "Gentleman" Music Video Demolishing YouTube Records

Source: http://www.thehollywoodgossip.com/2013/04/psy-gentleman-music-video-demolishing-youtube-records/

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Reese Witherspoon & Jim Toth -- Back to Business After ... - TMZ.com

Reese Witherspoon & Hubby
Back to Business
After Embarrassing Arrests

Exclusive

0424_reese_witherspoon_x17
Reese Witherspoon
and husband Jim Toth aren't hiding in shame following their embarrassing weekend arrests ... they're facing life head-on.

Reese was all smiles today in L.A. getting out of her car ... and Jim was back to work as usual at CAA, where he's one of Hollywood's bigwig agents.

0424_jim_toth_fame_flynet
You'll recall, Reese and Jim were both arrested in Atlanta on Friday -- Jim was popped for DUI ... and Reese was busted for disorderly conduct, after getting a little too worked up in her husband's defense.

According to police, Reese told one officer, "You're about to find out who I am ... You are going to be on national news."

Reese later released a statement, saying she was "deeply embarrassed" by what she had said.

Source: http://www.tmz.com/2013/04/24/reese-witherspoon-jim-toth-photos-pics-arrest-dui-disorderly-conduct/

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Thursday, April 25, 2013

Senate weighs move to stop airline flight delays: aide (reuters)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301520851?client_source=feed&format=rss

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Nasal lining used to breach blood/brain barrier

Apr. 24, 2013 ? Neurodegenerative and central nervous system (CNS) diseases represent a major public health issue affecting at least 20 million children and adults in the United States alone. Multiple drugs exist to treat and potentially cure these debilitating diseases, but 98 percent of all potential pharmaceutical agents are prevented from reaching the CNS directly due to the blood-brain barrier.

Using mucosa, or the lining of the nose, researchers in the department of Otology and Laryngology at the Massachusetts Eye and Ear/Harvard Medical School and the Biomedical Engineering Department of Boston University have demonstrated what may be the first known method to permanently bypass the blood-brain barrier, thus opening the door to new treatment options for those with neurodegenerative and CNS disease. Their study is published on PLOS ONE.

Many attempts have been made to deliver drugs across the blood-brain barrier using methods such as osmotic disruption and implantation of catheters into the brain, however these methods are temporary and prone to infection and dislodgement.

"As an endoscopic skull base surgeon, I and many other researchers have helped to develop methods to reconstruct large defects between the nose and brain using the patient's own mucosa or nasal lining," said Benjamin S. Bleier, M.D., Otolaryngologist at Mass. Eye and Ear and HMS Assistant Professor.

Study co-author Xue Han, Ph.D., an assistant professor of Biomedical Engineering at Boston University, said, "The development of this model enables us to perform critical preclinical testing of novel therapies for neurological and psychiatric diseases."

Inspired by recent advances in human endoscopic transnasal skull based surgical techniques, the investigators went to work to develop an animal model of this technique and use it to evaluate transmucosal permeability for the purpose of direct drug delivery to the brain.

In this study using a mouse model, researchers describe a novel method of creating a semi-permeable window in the blood-brain barrier using purely autologous tissues to allow for higher molecular weight drug delivery to the CNS. They demonstrated for the first time that these membranes are capable of delivering molecules to the brain which are up to 1,000-times larger than those excluded by the blood-brain barrier.

"Since this is a proven surgical technique which is known to be safe and well tolerated, this data suggests that these membranes may represent the first known method to permanently bypass the blood-brain barrier using the patient's own tissue," Dr. Bleier said. "This method may open the door for the development of a variety of new therapies for neurodegenerative and CNS disease.

Future studies will be directed towards developing clinical trials to test this method in patients who have already undergone these endoscopic surgeries."

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Story Source:

The above story is reprinted from materials provided by Massachusetts Eye and Ear Infirmary.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Benjamin S. Bleier, Richie E. Kohman, Rachel E. Feldman, Shreshtha Ramanlal, Xue Han. Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain. PLoS ONE, 2013; 8 (4): e61694 DOI: 10.1371/journal.pone.0061694

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/gkF2Z1R2mSc/130424185207.htm

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NY college crew team finds giant floating 'head'

POUGHKEEPSIE, N.Y. (AP) ? Anyone lose a giant head made of Styrofoam and fiberglass?

That's what officials at an upstate New York college are asking after the men's crew team found the unusual object floating in the Hudson River.

Officials at Marist College in Poughkeepsie say the team was practicing earlier this week when the coach spotted a large object floating near the river's west bank. He hooked a rope to it and towed it to the team's dock on the east bank.

The object turned out to be a 7-foot-tall replica of a man's head made with Styrofoam and fiberglass. The head has the appearance of a Greek or Roman-style statue.

College officials believe it's a theater prop, but so far no one has come forward to claim the giant head.

Source: http://news.yahoo.com/ny-college-crew-team-finds-giant-floating-head-121543229.html

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One More Reason to Bike to Work: A Pedal-Powered Charger

One More Reason to Bike to Work: A Pedal-Powered Charger
Siva Cycles hopes to provide the developing world with power by giving you the ability to charge your mobile device while you pedal your bicycle.

Source: http://feedproxy.google.com/~r/GearFactor/~3/rBGilM60sIE/

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Wednesday, April 24, 2013

90% Beyond The Hills

All Critics (77) | Top Critics (30) | Fresh (69) | Rotten (8)

The final shot, with windshield wipers struggling to clean away a torrent of muddy water, suggests that no human agency is great enough to handle this world's misery.

"Beyond the Hills" seethes with astonishment and rage at a broken society marooned between the 21st century and the 16th.

It is a haunting movie, dealing with superstitions, possession, even exorcism, one in which Mungiu poses no easy answers, because there are none to be found.

If you long for the bleak intelligence of an Ingmar Bergman film, where humankind is deeply flawed and God is indifferently silent and the landscape is cloaked in perpetual winter, then Beyond the Hills promises to be your cup of despair.

There are no easy villains or heroes in this sad and slow but forcefully told tale, which exhibits the same humanity Mungiu brought to 4 Months, 3 Weeks and 2 Days, his abortion drama that won the 2007 Palme d'Or.

A film that asks its viewer to consider the nature of good and evil, love and trust - and trust that turns into something like blind faith.

(Writer-director Christian) Mungiu balances his film's more disturbing content with peaceful shots of the idyllic, surrounding countryside and of intimacy between the two women while slowly building to an inevitable conclusion.

When the ill and unstable Alina returns to the monastery, just so she can be with her beloved, Beyond the Hills becomes a species of those exorcism movies that audiences gorge on, only done with a realism and ambiguity usually missing from the genre.

What makes this movie unique is that it holds literally everyone in the film accountable for the unfortunate goings on.

It's an exorcism movie for everyone who thought, after Mungiu's gruelling abortion buddy-movie 4 Months, 3 Weeks and 2 Days, that this guy should do an exorcism movie

It's an enigmatic and austere film from a region where political, sexual and religious repression are as stifling as the sooty air.

Mungui's rigorous approach to filmmaking isn't a ton of fun to watch, but his ideas stick with you.

It delivers an emotional punch, in what its director has called a story about the sin of indifference.

Such is the rigorous and high-minded nature of Romanian cinema that even a real-life exorcism story can inspire something loftier than a horror movie.

Heartbreak at a Romanian convent

...Cristian Mungiu has taken a real life event...to consider deeply human philosophies such as freedom vs. discipline, love vs. security, the choices facing those without financial recourse and the hypocrisies of organized religions.

I found it riveting to watch and fascinating to think about afterwards.

An undeniably tough watch.

Stark, deadpan, and darkly dry.

With this viscerally involving drama, acclaimed Romanian filmmaker Mungiu (4 Months, 3 Weeks and 2 Days) tells another strikingly original story of women caught between old and new world beliefs.

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Source: http://www.rottentomatoes.com/m/beyond_the_hills_2012/

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A Cheat Sheet of Every Single Gmail Keyboard Shortcut

Do you use Gmail a lot? Then you need to see this graphic with all the keyboard shortcuts that can make like a million times easier. It comes complete with visualizations of each action, for some reference of what you're actually accomplishing. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Q3AKssXR3gA/a-cheat-sheet-of-every-single-gmail-keyboard-shortcut

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